A major part of ground water resources is used for irrigation of farm lands. So appropriate management should be applied considered for application of these limited resources. In this research, 30 wells were selected over three time steps 1998, 2002 and 2009 in Mosafer Abad plain of Hormozgan province and some chemical properties such as Na, Cl, EC, pH, TDS, TH and SAR were analysed for zoning at the mentioned time steps. The purpose of this study is to determine the most appropriate interpolation method to analyze the spatial variability of landscape characteristics of groundwater quality of Mosafer Abad plain using Kriging, IDW (Inverse Distance Weighting and RBF (Radial Basis Functions) methods. Result shows that Kriging method with RMSE values ​​ lower than other methods is more acceptable approach for the study area. Meanwhile, the results revealed that average depletion of water table levels in at 1998, 2002 and 2009 are -0.152, 0.629 and -0.384 meter, respectively. This Represents a decreasing trend in groundwater level in wells and indicates a meaningful warning for more attention to ground water resources in Mosafer Abad plain.